(+)-D-threo–PDMP (hydrochloride)
(+)-D-threo–PDMP (hydrochloride)
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is...
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€182.00 €154.70
€182.00 €154.70
Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.{26479} It has antimalarial and anticoccidial actions.{26479} In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-? signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells.{26479,26481} Through this action, halofuginone blocks fibrosis and tumor progression in a variety of different models.{26479,26482} This compound also competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), activating the amino acid starvation response.{26480,17217} This prevents the differentiation of TH17 cells, blunting an autoimmune response.{17217}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 5 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 1217623-74-9 |
| Molecular formula | C16H17BrClN3O3 • HCl |
| Smiles | BrC1=C(Cl)C=C2C(N=CN(CC(C[C@H]3NCCC[C@@H]3O)=O)C2=O)=C1.Cl |
| Molecular weight | 451,1 |
| Custom code | 2903.99 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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