H-Ile-Pro-Pro<wbr/>-OH (trifluoro<wbr/>acetate salt)

H-Ile-Pro-Pro-OH (trifluoroacetate salt)

CAT N°: 28899
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From 66.00 56.10

H-Ile-Pro-Pro-OH (IPP) is a peptide inhibitor of angiotensin converting enzyme (ACE; IC50 = 5 µM).{49410} It inhibits acetylcholine-induced nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 µM and induces vasorelaxation in precontracted isolated rat aortic rings.{49411} IPP (0.3 mg/kg) decreases systolic blood pressure in spontaneously hypertensive, but not normotensive, rats.{49414} Dietary administration of IPP reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, mRNA expression of IL-6 and IL-1?, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE-/- mice.{49412}

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