GW 9662

GW 9662

CAT N°: 70785
Price:

From 17.00 14.45

The peroxisome proliferator-activated receptor ? (PPAR?) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR? agonists with antidiabetic actions in vivo.{7575,8224} Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class.{8241} There are many PPAR? agonists, including 15-deoxy-?12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived.{8461,8930} However, only a few antagonists have been reported.{8953} GW 9662 blocks the PPAR?-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.{8953} It is therefore a much more potent antagonist than BADGE, which is another reported PPAR? antagonist.{9318}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-chloro-5-nitrobenzanilide
  • Correlated keywords
    • GW-9662 GW9662 ligands ppar.gamma. ppargamma peroxisome proliferator-activated nuclear endocrinology receptors antagonists atherosclerosis
  • Product Overview:
    The peroxisome proliferator-activated receptor ? (PPAR?) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR? agonists with antidiabetic actions in vivo.{7575,8224} Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class.{8241} There are many PPAR? agonists, including 15-deoxy-?12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived.{8461,8930} However, only a few antagonists have been reported.{8953} GW 9662 blocks the PPAR?-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.{8953} It is therefore a much more potent antagonist than BADGE, which is another reported PPAR? antagonist.{9318}

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