GW 441756

GW 441756

CAT N°: 16915
Price:

From 66.00 56.10

The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis.{27678,27676} GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM).{27675} It displays >100-fold selectivity over a panel of related kinases.{27675} GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-? protein precursor cleavage in neuroglioma cells.{27677,27674}

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