GW 2580

GW 2580

CAT N°: 15411
Price:

From 55.00 46.75

cFMS kinase is the cellular homolog of the v-FMS oncogene product of the Susan McDonough strain of the feline sarcoma virus. It can autophosphorlyate colony-stimulating factor (CSF-1), which promotes the survival, proliferation, and differentiation of mononuclear phagocytes. GW 2580 selectively inhibits cFMS kinase (IC50 = 0.03 ?M), preventing CSF-1-induced monocyte growth with an IC50 value of 0.14 ?M.{25081} At 75-100 mg/kg, it has been shown to inhibit joint connective tissue and bone degradation in mouse models of arthritis.{25081}

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