GW 1929

GW 1929

CAT N°: 13689
Price:

From 59.00 50.15

Peroxisome proliferator-activated receptor (PPAR) ? is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism.{15751} The best known class of PPAR? ligands are the thiazolidinediones, including troglitazone (Item No. 71750) and rosiglitazone (Item No. 71740).{8461} GW 1929 is a non-thiazolidinedione activator of PPAR? that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes.{25251} It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes.{25251,25253} Both in vitro and in vivo effects of GW 1929 on PPAR? greatly exceed those produced by troglitazone.{25251,25253} In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.{25252}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine
  • Correlated keywords
    • receptors agonists PPARs diabetes metabolic syndromes nuclear neurosciences inflammation PPAR? PPARg PPARgamma PPAR.gamma. PPAR-? PPAR-g PPAR-gamma PPAR-.gamma. ? g gamma .gamma. peroxisomes proliferator-activated proliferator activated non-thiazolidinedione activator activates activation GW1929 GWs 1929 GW-1929 anti-hyperglycemic anti-hyperlipidemic hyperglycemic hyperlipidemic anti thiazolidinedione non nonthiazolidinedione antihyperlipidemic antihyperglycemic type 2
  • Product Overview:
    Peroxisome proliferator-activated receptor (PPAR) ? is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism.{15751} The best known class of PPAR? ligands are the thiazolidinediones, including troglitazone (Item No. 71750) and rosiglitazone (Item No. 71740).{8461} GW 1929 is a non-thiazolidinedione activator of PPAR? that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes.{25251} It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes.{25251,25253} Both in vitro and in vivo effects of GW 1929 on PPAR? greatly exceed those produced by troglitazone.{25251,25253} In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.{25252}

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