Guanfacine (hydrochloride)

Guanfacine (hydrochloride)

CAT N°: 22907
Price:

From 74.00 62.90

Guanfacine is an ?2-adrenergic receptor (?2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for ?2A-, ?2B-, and ?2C-ARs, respectively, in a radioligand binding assay.{40326} It has EC50 values of 52, 288, and 602 nM for ?2A-, ?2B-, and ?2C-ARs, respectively, for stimulated [35S]GTP?S binding. It also binds to imidazoline receptor 1 (Ki = 19 nM in a radioligand binding assay).{40341} Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.{40342} It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.{40340} Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide, monohydrochloride
  • Correlated keywords
    • 29110-47-2 BS 100-141 BS100-141 BS 100141 BS100141 Estulic INTUNIV LON 798 LON798 SPD-503 SPD503 Tenex
  • Product Overview:
    Guanfacine is an ?2-adrenergic receptor (?2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for ?2A-, ?2B-, and ?2C-ARs, respectively, in a radioligand binding assay.{40326} It has EC50 values of 52, 288, and 602 nM for ?2A-, ?2B-, and ?2C-ARs, respectively, for stimulated [35S]GTP?S binding. It also binds to imidazoline receptor 1 (Ki = 19 nM in a radioligand binding assay).{40341} Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.{40342} It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.{40340} Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).

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