Guanethidine (sulfate)

Guanethidine (sulfate)

CAT N°: 16217
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From 85.00 72.25

Guanethidine is an antihypertensive compound that competes with norepinephrine for transport into presynaptic terminals of adrenergic neurons by the norepinephrine transporter.{26665} Once guanethidine has entered the nerve, it becomes concentrated in synaptic vesicles, depleting endogenous norepinephrine, and thus, reducing the release of norepinephrine in response to action potentials.{26665} Guanethidine’s actions are restricted to peripheral nerve terminals because its basic guanidine group does not allow passage through the blood brain barrier.{26665} Its use has been explored in the relief of chronic pain caused by complex regional pain syndrome.{26666}

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