GSK4716

GSK4716

CAT N°: 17233
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The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor ?-coactivator 1? (PGC-1?) to this class of receptors is known to potentiate ERR activity.{12071} GSK4716 is an ERR?/? agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand, PGC-1?.{28181} It is more than 50-fold selective for binding to ERR?/? compared with the estrogen receptors.{28181} This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.{28182}

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TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

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