GSK429286A

GSK429286A

CAT N°: 15262
Price:

From 51.00 43.35

GSK429286A is a cell-permeable inhibitor of Rho-associated kinase (IC50 = 14 nM).{26327} It less potently inhibits p90 and p70 ribosomal S6 kinases (IC50s = 780 and 1,940 nM, respectively) and is ineffective against leucine-rich repeat protein kinase-2.{26327,26328} GSK429286A reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM) and produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats.{26327}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyridinecarboxamide
  • Correlated keywords
    • inhibitor inhibit kinase protein hypertension intracellular signaling signal cell-permeable ROCK Rho-associated Rho associated arterial pressures hypertensive GSK-429286
  • Product Overview:
    GSK429286A is a cell-permeable inhibitor of Rho-associated kinase (IC50 = 14 nM).{26327} It less potently inhibits p90 and p70 ribosomal S6 kinases (IC50s = 780 and 1,940 nM, respectively) and is ineffective against leucine-rich repeat protein kinase-2.{26327,26328} GSK429286A reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM) and produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats.{26327}

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