€641.00 €544.85
GPR99 is a G protein-coupled receptor (GPCR) that was originally identified as a purinergic receptor, P2Y15.{47265,47266} However, it is activated by leukotriene E4 (LTE4; Item No. 20410) in the low nanomolar range and by ?-ketoglutarate in the high micromolar range.{23197,19519} It is found in the CNS, kidney, epididymis, and other tissues in the mouse, as well as in human kidney, nasal turbinates, and lung, among other tissues.{47267,47268} GPR99 knockout in mice prevents vascular leakage induced by LTE4 and epithelial cell mucin release in mouse nasal mucosa induced by LTE4 or A. alternata.{23197} In the kidney, under acid-base stress, it is involved with the regulation of carbonic acid and sodium chloride resorption through activation by ?-ketoglutarate.{47267} GPR99 is also expressed in mouse retina, and axon growth is increased when it is activated by ?-ketoglutarate in isolated mouse embryo retinal explants.{47269} Cayman’s GPR99 (C-Term) Polyclonal Antibody can be used for Western blot and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminus of GPR99 from human samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Synthetic peptide from the C-terminal region of human GPR99 |
| Application(s) | IHC, WB |
| Formulation | 500 µl of peptide affinity-purified antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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