Gö 6976

Gö 6976

CAT N°: 13310
Price:

From 74.00 62.90

Gö 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKC? and PKC?1, respectively.{9057} It does not inhibit the activity of PKC?, PKC?, or PKC? (IC50s > 3 ?M), indicating a preference for the Ca2+-dependent subtypes, PKC? and PKC?1.{9057} Gö 6976 also inhibits the checkpoint kinases Chk1/2.{30717} It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.{30717,24026}

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