Glyburide (potassium salt)

Glyburide (potassium salt)

CAT N°: 15009
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From 145.00 123.25

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).{22674} It binds to microsomes derived from RINm5F pancreatic ?-cells (Kd = 0.3 nM) and inhibits 86Rb+ efflux from intact RINm5 cells with a half-maximal inhibition (K0.5) value of 0.06 nM.{22672} Glyburide (5 mg/kg) reduces blood glucose levels and increases the activity of hepatic glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{43282} It inhibits ATP-induced increases in caspase-1 activation and IL-1? and IL-18 secretion in a concentration-dependent manner in LPS-primed bone marrow-derived macrophages (BMDMs).{22671} Glyburide (80 mg/ml) also reduces lesion growth in mice infected with L. mexicana.{22673} Formulations containing glyburide have been used in the treatment of type 2 diabetes.

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