24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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€348.00 €295.80
€348.00 €295.80
Glimepiride-d4 is intended for use as an internal standard for the quantification of glimepiride (Item No. 12090) by GC- or LC-MS. Glimepiride is a long-acting sulfonylurea that inhibits ATP-sensitive potassium (KATP) channels in pancreatic ?-cells (IC50 = 3 nM), which leads to the release of insulin.{25521} At 20 ?M, glimepiride has been shown to increase the activity of intracellular insulin receptors and to prevent insulin receptor downregulation during chronic insulin stimulation through a mechanism involving protein kinase C activation.{25523} It has been reported to be less effective at inhibiting nonpancreatic KATP channels, and therefore contributes fewer cardiac actions, compared to earlier generations of sulfonylurea anti-type 2 diabetes treatments.{25522}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C24H30D4N4O5S |
| Smiles | O=S(C1=CC=C(C([2H])([2H])C([2H])([2H])NC(N2C(C(CC)=C(C)C2)=O)=O)C=C1)(NC(NC3CCC(C)CC3)=O)=O |
| Molecular weight | 494,6 |
| Formulation | A solid |
| Purity | ≥99% deuterated forms (d1-d4) |
| Custom code | 3822.19 |
| UNSPSC code | 12352100 |
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