Gestodene

Gestodene

CAT N°: 18217
Price:

66.00 56.10

Gestodene is a progestin.{12452} It selectively binds to the progesterone receptor over the estrogen receptor.{61327} Gestodene induces transcriptional activity mediated by the progesterone receptor, and, weakly, the androgen receptor in reporter assays.{61328} It increases the growth of MCF-7 cells when used at concentrations ranging from 0.1 to 1 µM.{61329} In contrast, gestodene (0.1 mg/kg) reduces tumor growth in an estrogen-dependent model of rat mammary tumors induced by DMBA (Item No. 30383). Formulations containing gestodene, in combination with ethynyl estradiol have been used as oral contraceptives.

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