Geraniol

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 3,7-dimethyl-2E,6-octadien-1-ol
• Correlated keywords
  • 8007-13-4 491611-08-6 oxidant antiinflammatory cancer Callosobruchus TNF? IL6 IL1? 1-? COLO205 60 980 BJ Geranyl alcohol Lemonol MosquitoSafe Mosquito Safe NSC9279 TT-4228 4302 TT4228 TT4302 trans microbial nerol
• Product Overview:
  Geraniol is a terpene alcohol found in a variety of plants, including Cannabis, that has diverse biological activities, including insecticide, antioxidant, anti-inflammatory, anticancer, and antimicrobial properties.{42303,39970} Geraniol is an insecticide that induces 100% mortality of C. maculatus, when used at a concentration of 16 µl in an alimentary substrate.{39971} It has an LD50 value of 0.714 µl in C. maculatus but does not produce adverse effects in rats when administered in the diet at 10,000 ppm for 16 weeks.{39971,39970} Topical administration of geraniol (250 µg) prevents lipid peroxidation, increases glutathione (GSH) levels, and increases the activity of antioxidant enzymes, including catalase, glutathione reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase in a mouse skin model of oxidative stress and inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{39972} It also decreases the levels of TNF-?, IL-6, and IL-1? in the same model. Geraniol (100 mg/kg) inhibits HMG-CoA reductase and reduces lipogenesis in hamsters fed an atherogenic diet as a model of hyperlipidemia when administered at a dose of 100 mg/kg.{39973} It also induces apoptosis in and decreases viability of COLO 205 cancer cells (IC50 = 20 µM).{42326} Formulations containing geraniol have been used as fragrance ingredients and as insecticides in agriculture.