GDC-0941

GDC-0941

CAT N°: 11600
Price:

From 202.00 171.70

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.{13740,17822} GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110?, ?, ?, and ? with IC50 values of 3, 33, 3, and 75 nM, respectively.{24602,24604} It is much less effective against class II-IV isoforms of PI3K and against mTOR.{24602,24603} GDC-0941 inhibits the growth of certain types of cancer cells and blocks signaling through PI3K to Akt, both in cells and in vivo.{24602,24605}

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