Gap-43 (Phospho-Ser41) Polyclonal Antibody

CAT N°: 10009400
Price:

680.00 578.00

Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration.{14428} There is also evidence from knockout animals that Gap-43 serves to amplify path finding signals from the growth cone.{14431} Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C (Catalog No. 1609-PKC) modulates the interaction of Gap-43 with actin and may also affect neurotransmitter release during forms of plasticity like LTP.{14429,14430}

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • GAP43 development and plasticity neuronal growth cones axonal regeneration knockout animals amplify path finding signals mediate actin phosphorylation kinases C PKC modulates neurotransmitters LTP antibodies antisera antiserum WB western blots IHC immunohistochemistry frozen sections blotting proteins diseases phospho-specific immunoblotting
  • Product Overview:
    Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration.{14428} There is also evidence from knockout animals that Gap-43 serves to amplify path finding signals from the growth cone.{14431} Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C (Catalog No. 1609-PKC) modulates the interaction of Gap-43 with actin and may also affect neurotransmitter release during forms of plasticity like LTP.{14429,14430}

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