Gap 26 (trifluoro<wbr/>acetate salt)

Gap 26 (trifluoroacetate salt)

CAT N°: 36625
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From 100.00 85.00

Gap 26 is a connexin-mimetic peptide that corresponds to amino acids 63-75 of extracellular loop 1 in connexin 43.{67015} It inhibits phenylephrine-induced rhythmic contractile activity in isolated rabbit superior mesenteric arterial strips (IC50 = 28.4 µM). Gap 26 (0.25 mg/ml) inhibits photoliberated Ins(1,4,5)-P3-induced ATP release in ECV304 cells.{67016} It decreases the infarct size in a rat model of myocardial infarction induced by left coronary artery occlusion when administered at doses of 0.5, 1, and 10 µg/kg.{67017}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-valyl-L-cysteinyl-L-tyrosyl-L-?-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-L-arginine, trifluoroacetate salt
  • Correlated keywords
    • 2757470-18-9 197250-15-0 gap26 connexin43 ecv 304 phenyl ephrine photo liberated
  • Product Overview:
    Gap 26 is a connexin-mimetic peptide that corresponds to amino acids 63-75 of extracellular loop 1 in connexin 43.{67015} It inhibits phenylephrine-induced rhythmic contractile activity in isolated rabbit superior mesenteric arterial strips (IC50 = 28.4 µM). Gap 26 (0.25 mg/ml) inhibits photoliberated Ins(1,4,5)-P3-induced ATP release in ECV304 cells.{67016} It decreases the infarct size in a rat model of myocardial infarction induced by left coronary artery occlusion when administered at doses of 0.5, 1, and 10 µg/kg.{67017}

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