24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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From €109.00 €92.65
Gallein is an inhibitor of G protein ?? subunit-dependent signaling.{61667} It binds to G?1?2 in a cell-free assay (IC50 = 200 nM) and inhibits G??-dependent activation of PI3K in HL-60 cells. Gallein (10 µM) also inhibits Rac1 activation, superoxide production, and chemotaxis induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in differentiated HL-60 cells. In vivo, gallein (10 mg/kg per day) increases survival, reduces ventricular hypertrophy, and attenuates cardiac remodeling in a mouse model of heart failure induced by transverse aortic constriction (TAC).{61668}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 mg, 250 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 2103-64-2 |
| Molecular formula | C20H12O7 |
| Smiles | OC1=C(O)C2=C(C=C1)C3(C(C=CC=C4)=C4C(O3)=O)C5=CC=C(O)C(O)=C5O2 |
| Molecular weight | 364,3 |
| Custom code | 2918.99 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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