€667.00 €566.95
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.{46949,46950} They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: ?1-6, ?1-4, ?1-3, ?, ?, ?, ?, and ?1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by ?1?2?2 subunit-containing GABAA receptors, the major isoform found in the brain.{46950,46951} The ? subunit of GABAA receptors interfaces with a ? subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the ? subunit. Activation of GABAA receptors with the ?2/?3-selective GABAA receptor agonist SL651498, but not the ?5/?3 selective GABAA receptor positive allosteric modulator NS 11394 (Item No. 23872), suppresses cortical spreading depression, the underlying cause of migraine, in isolated chick retina.{55214} Point mutation of the histidine residue at position 101 (H101R) of the GABAA ?2 subunit inhibits muscle relaxation and the anxiolytic-like effects of the benzodiazepine diazepam in mice.{46949} Expression of GABRA2, which encodes the ?2 subunit isoform, is upregulated in ipsilateral, but not contralateral, perilesional tissue in a rat model of cortical ischemia-reperfusion injury.{55094} Cayman’s GABAA Receptor ?2 Subunit Polyclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor ?2 subunit at approximately 51 kDa from murine samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Fusion protein from the cytoplasmic loop of the ?2 subunit of the rat GABAA receptor |
| Application(s) | ICC, WB |
| Formulation | 100 µl of affinity-purified polyclonal antibody from pooled serum |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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