G10

G10

CAT N°: 22353
Price:

From 49.00 41.65

G10 is an indirect activator of stimulator of interferon genes (STING) signaling.{37248} It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-?B-dependent transcription of IL-8, IL-1?, or MIP-1? in human fibroblasts. However, G10 does increase expression of NF-?B-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
  • Correlated keywords
    • G-10 IRF-3 NFkB IL1? IL8 IL1B MIP1a MIP1? macrophage inflammatory protein
  • Product Overview:
    G10 is an indirect activator of stimulator of interferon genes (STING) signaling.{37248} It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-?B-dependent transcription of IL-8, IL-1?, or MIP-1? in human fibroblasts. However, G10 does increase expression of NF-?B-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

We also advise you