24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Flutamide is an androgen receptor antagonist (Kis = 1.3 and 7.5 µM for the cytosolic rat ventral prostate and anterior pituitary receptors, respectively) and a prodrug form of 2-hydroxy flutamide (Item No. 15271).{24727} Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{24727} It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively.{54819} Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model.{54820} Formulations containing flutamide have been used in the treatment of prostate cancer.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 10 g, 25 g, 5 g |
|---|---|
| Shipping | room temp. |
| CAS number | 13311-84-7 |
| Molecular formula | C11H11F3N2O3 |
| Smiles | O=C(C(C)C)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 |
| Molecular weight | 276,2 |
| Custom code | 2922.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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