24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively).{8427} Flufenamic acid inhibits TNF-?-induced increases in COX-2 levels and NF-?B activation in HT-29 colon cancer cells in a concentration-dependent manner.{8510} It inhibits calcium influx induced by fMLP (fMLF; Item No. 21495) or A23187 (Item No. 11016) in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively.{1819} Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and large-conductance calcium-activated potassium channel (KCa1.1).{60389} It also inhibits various ion channels, including TRPC3 and cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.{60390}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 g, 100 ?g, 250 g, 50 g |
|---|---|
| Shipping | dry ice |
| CAS number | 530-78-9 |
| Molecular formula | C14H10F3NO2 |
| Smiles | OC(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)=O |
| Molecular weight | 281,2 |
| Custom code | 2922.49 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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