FLI-06

FLI-06

CAT N°: 21272
Price:

From 122.00 103.70

FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of ?-secretase and ?-secretase cleavage.{33469} It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum (ER) and converting ER morphology from tubule to sheet.{33469} FLI-06 is reported to alter the maturation pattern of amyloid precursor protein (APP) and prevent the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid ?.{33469}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid, cyclohexyl ester
  • Correlated keywords
    • FLI06 notch ?secretase ?-secretase ?secretase ?-secretase amyloid endoplasmic reticulum ER amyloid-precursor-protein APP HEK293 HEK-293 Golgi apparatus
  • Product Overview:
    FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of ?-secretase and ?-secretase cleavage.{33469} It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum (ER) and converting ER morphology from tubule to sheet.{33469} FLI-06 is reported to alter the maturation pattern of amyloid precursor protein (APP) and prevent the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid ?.{33469}

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