FIPI

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide
• Correlated keywords
  • Phospholipases D PLD phosphatidic acids PA Ras activation cells spreading stress fiber formation chemotaxis membrane vesicles trafficking halopemide inhibitors inhibits inhibition PLD1 PLD2 F-actin cytoskeletons inflammation arthritis Pharmascience Brand of Domperidone Maleate Stadapharm Brand of Domperidone Maleate Ratiopharm Brand of Domperidone Maleate Taxandria Brand of Domperidone Maleate Novopharm Brand of Domperidone Maleate Nu-Pharm Brand of Domperidone Maleate Nu Pharm Brand of Domperidone Maleate Apotex Brand of Domperidone Maleate Hexal Brand of Domperidone Maleate Aliud Brand of Domperidone Maleate Teva Brand of Domperidone Maleate Pierre Fabre Brand of Domperidone Gry Brand of Domperidone Maleate Rottapharm Brand of Domperidone Monohydrochloride, Domperidone Domperidone Monohydrochloride Janssen Brand of Domperidone Domperidone Maleate (1:1) Maleate, Domperidone Domperidone Maleate Gamir Domperidona Stada Domperidon ratio-Domperidone ratio Domperidone Hexal Domperidon Domperidona Gamir Novo-Domperidone Novo Domperidone Domperidon Stada Domperidon Hexal PMS-Domperidone PMS Domperidone Domperidon-TEVA Domperidon TEVA Apo-Domperidone Apo Domperidone Nu-Domperidone Nu Domperidone Domperidon AL Domperidone Gastrocure Domperidon R-33,812 Nauzelin Motilium R-33812 R33,812 Péridys Domidon R33812
• Product Overview:
  Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM).{17399,17462} It also prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.{17399} FIPI has good pharmacokinetic parameters in rats, with a half-life greater than five hours, a Cmax that, at 363 nM, is greater than 10-fold the IC50 versus PLD2, and bioavailability of 18%.{17462}