From €590.00 €501.50
Fibroblast growth factor 10 (FGF10) is a member of the paracrine subfamily of FGFs that mediates mesenchymal to epithelial signaling.{54156} It is a secreted protein that contains a typical N-terminal signal sequence and is expressed exclusively in the mesenchyme. FGF10 binds to FGF receptor 2b (FGFR2B) in the epithelium, either alone or in a ternary complex with heparan sulfate, to induce intracellular signaling. FGF10 is essential to organ development and Fgf10 knockout mice exhibit limb, lung, thyroid, anterior pituitary, and salivary gland agenesis, as well as tooth, hair follicle, inner ear, thymic, pancreatic, and glandular stomach dysgenesis. Inherited heterozygous loss-of-function mutations in FGF10 cause aplasia of lacrimal and salivary glands (ALSG), Lacrimo-auriculo-dento-digital (LADD) syndrome, and chronic obstructive pulmonary disease (COPD) in humans. SNPs in FGF10 are highly associated with cleft lip and/or palate and extreme myopia, or near-sightedness, in humans.{54157} FGF10 is overexpressed in some human breast carcinomas and FGF10 induces migration and metastasis of prostate cancer cells in vitro.{54156,54158} Cayman’s FGF10 (human, recombinant) protein consists of 172 amino acids and has a calculated molecular weight of 19.6 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Custom code | 3504.00 |
| Formulation | Lyophilized from sterile PBS, pH 7.4, with 1 mM DTT, 5-8% trehalose, mannitol, and 0.01% Tween 80 |
| Purity | ≥95% estimated by SDS-PAGE |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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Endocannabinoids, such as arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG), function as short-range modulators of cell and synaptic activity. Monoacylglycerol...
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CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells.{59706,59704} It...
The cyclopentenone prostaglandin HPLC mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors supplied in methyl acetate....
The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype...
Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in...
Adenosine Receptor A2A is a multi-pass membrane protein that is normally localized to the plasma membrane.{15465} This receptor is part...
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