€336.00 €285.60
Ferritin is a spherical protein involved in iron storage and biomineralization.{55228,53730} It is primarily localized to the cytoplasm, but is also present in the mitochondria and nucleus, and is composed of 24 protein subunits with a tissue-specific ratio of ferritin heavy chains (FTH1s; Item No. 32033) to ferritin light chains (FTLs). FTH1 and FTL are nearly identical in overall conformation but only share approximately 50% sequence homology.{53731} FTH1 functions as a ferroxidase that catalyzes the oxidation of Fe(II) to Fe(III), and FTL has roles in iron nucleation and protein stability. FTL is overexpressed in acute myeloid leukemia and leukemic stem cells compared with normal hematopoietic stem cells.{53732} Nucleotide duplications in FTL are associated with neuroferritinopathy, an autosomal dominant neurodegenerative disease characterized by the presence of intracellular ferritin inclusion bodies and iron accumulation in glia and neurons throughout the CNS.{53731} Point mutations in the 5’-UTR of FTL have been found in individuals with hereditary hyperferritinemia-cataract syndrome.{53733} Cayman’s Ferritin Light Chain (human, recombinant) protein consists of 191 amino acids and has a calculated molecular weight of 22.1 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | Lyophilized from sterile 50 mM Tris, pH 9.5, with 20% glycerol |
| Purity | ≥95% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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