€724.00 €615.40
Fatty acid desaturase 2 (FADS2), also known as ?6-desaturase, is a 444-amino acid transmembrane protein encoded by FADS2.{49056} This product is the N-terminal cytoplasmic domain of FADS2, corresponding to residues 2-131 of the full-length sequence. It catalyzes the rate-limiting step in the conversion of the ?-6 and ?-3 precursors linoleic acid (Item Nos. 90150 | 21909) and ?-linolenic acid (Item No. 90210) to their respective long-chain polyunsaturated fatty acids (LC-PUFAs), inserting a cis double bond at position 6 of the fatty acid chain to convert linoleic acid to ?-linolenic acid (Item No. 90220) and ?-linolenic acid to stearidonic acid (Item No. 90320), respectively. Following secondary desaturation by FADS1 (Item No. 25827) and chain elongation, FADS2 catalyzes desaturation of 24-carbon LC-PUFA intermediates. FADS2 also catalyzes the desaturation of palmitic acid (Item No. 10006627) to sapienic acid in human sebaceous glands and in various cancer cell lines that express FADS2.{45162,43766} Hepatic FADS2 protein levels and mRNA expression are increased in mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH).{43213} FADS2 knockout (fads2-/-) mice are infertile, resistant to obesity, and have altered subcellular membrane diacylglycerol composition which leads to dysregulated post-translational processing of SREBP1c, a key transcription factor in the regulation of lipid metabolism.{45163}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol |
| Purity | ≥95% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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