Ezutromid

Ezutromid

CAT N°: 20309
Price:

383.00 325.55

Ezutromid is a modulator of utrophin production.{32729} It upregulates utrophin production in mouse myoblasts (EC50 = 0.91 µM in a reporter assay).{68213} It inhibits the activity of the cytochrome P450 (CYP) isoform CYP1A2 in pooled human liver microsomes (IC50 = 5.4 µM).{68214} Chronic administration of ezutromid (50 mg/kg) increases utrophin protein levels in the heart, increases grip strength, and decreases fatigue, indicated by distance traveled during forced exercise, in the mdx mouse model of muscular dystrophy.{32729}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-(ethylsulfonyl)-2-(2-naphthalenyl)-benzoxazole
  • Correlated keywords
    • BMN195 SMTC1100 VOXC1100
  • Product Overview:
    Ezutromid is a modulator of utrophin production.{32729} It upregulates utrophin production in mouse myoblasts (EC50 = 0.91 µM in a reporter assay).{68213} It inhibits the activity of the cytochrome P450 (CYP) isoform CYP1A2 in pooled human liver microsomes (IC50 = 5.4 µM).{68214} Chronic administration of ezutromid (50 mg/kg) increases utrophin protein levels in the heart, increases grip strength, and decreases fatigue, indicated by distance traveled during forced exercise, in the mdx mouse model of muscular dystrophy.{32729}

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