ERGi-USU

ERGi-USU

CAT N°: 30875
Price:

From 49.00 41.65

ERGi-USU is an inhibitor of the oncoprotein ETS-related gene (ERG; IC50 = 315 nM).{52670} It inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but not LNCaP, LAPC4, and MDA PCa 2b prostate cancer and human umbilical vein endothelial cells (HUVECs), which do not express ERG (IC50s = >10 µM for all). ERGi-USU (100 and 150 mg/kg) reduces tumor growth in a VCaP mouse xenograft model.

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