Epipregnanolone

Epipregnanolone

CAT N°: 34295
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Epipregnanolone is a neurosteroid and an active metabolite of the steroid hormone pregnenolone (Item No. 19864).{60528} It is enzymatically formed from pregnenolone via the intermediates progesterone (Item No. 15876) and 5?-dihydroprogesterone in the placenta.{60529} Epipregnanolone inhibits spontaneous contractions in myometrial strips isolated from at-term pregnant women (IC50 = 156 µM).{60530} Epipregnanolone (10 and 20 mg/kg) decreases operant alcohol self-administration in rats.{60531} Maternal plasma levels of epipregnanolone increase over the duration of pregnancy.

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