€424.00 €360.40
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) is a type II transmembrane glycoprotein with nucleotide pyrophosphatase and phosphodiesterase enzyme activities.{50816} It is expressed in skeletal, adipose, hepatic, renal, cardiac, and placental tissues, as well as pancreatic islets, salivary glands, chondrocytes, fibroblasts, and lymphocytes.{55569} ENPP1 is a critical regulator of purinergic signaling that catalyzes the hydrolysis of ATP or GTP to AMP or GMP, respectively, as well as the hydrolysis of cGAMP, and has roles in platelet aggregation, muscle contraction, hypoxia, ischemia, cGAS-STING signaling, and cell proliferation, migration, apoptosis, and differentiation.{50816,61210} This nucleotide hydrolysis also generates inorganic pyrophosphates, which inhibit bone and cartilage mineralization, implicating ENPP1 as a regulator of bone and cartilage development. Loss-of-function mutations in ENPP1 are associated with various calcification-related disorders, including autosomal recessive hypophosphatemic rickets type 2 (ARHR2) generalized arterial calcification of infancy (GACI), and pseudoxanthoma elasticum (PXE).{50816,55568} ENPP1 SNPs are associated with insulin resistance and the development of diabetic nephropathy.{55569,55567} ENPP1 hydrolysis of cGAMP in the tumor microenvironment decreases STING activation, facilitates immunosuppression, and is associated with enhanced bone metastasis in mouse xenograft models of breast cancer.{50816,61210} Inhibition of ENPP1 promotes STING activation and increases survival in various mouse xenograft models.{50816} Cayman’s ENPP1 (human, recombinant) protein can be used for enzyme activity assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | TBS, pH 7.4, with 5% glycerol |
| Purity | ≥90% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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