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Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ?-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this ?-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (?-6) arachidonic acid by cyclooxygenase enzymes, suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism.{16250} In addition, dietary EPA ethyl ester in rats increases fatty acid ?-oxidation enzyme levels, indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism.{16514,16499} Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-? expression.{16498}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg, 50 µg, 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C22H29D5O2 |
| Smiles | CC/C=CC/C=CC/C=CC/C=CC/C=CCCCC(OC([2H])([2H])C([2H])([2H])[2H])=O, CC/C=CC/C=CC/C=CC/C=CC/C=CCCCC(OC([2H])([2H])C([2H])([2H])[2H])=O, CC/C=CC/C=CC/C=CC/C=CC/C=CCCCC(OC([2H])([2H])C([2H])([2H])[2H])=O, CC/C=CC/C=CC/C=CC/C=CC/C=CCCCC(OC([2H])([2H])C([2H])([2H])[2H])=O |
| Molecular weight | 335,5 |
| Custom code | 3822.19 |
| Formulation | A solution in ethanol |
| Purity | ≥99% deuterated forms (d1-d5) |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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Protein phosphorylation is an important post-translational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein...
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10 bis avenue Ampère
78180 Montigny le Bretonneux
France
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