E3 Ligand-Linker Conjugate 3

E3 Ligand-Linker Conjugate 3

CAT N°: 36666
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E3 ligand-linker conjugate 3 is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies containing thalidomide (Item No. 14610), which is a ligand for the E3 ubiquitin ligase cereblon.{67087,67088} It has been used in the synthesis of PROTACs for the degradation of several proteins, including anaplastic lymphoma kinase (ALK) and the bromodomain and extra terminal domain (BET) family of proteins, with anticancer activity.

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