DPPE (fumarate)

DPPE (fumarate)

CAT N°: 35360
Price:

From 43.00 36.55

DPPE is a ligand for the antiestrogen-binding site (AEBS; Ki = 55.6 nM in rat liver microsomes) and derivative of tamoxifen (Item No. 11629).{57916} It is selective for the AEBS over the estrogen receptor when used at a concentration of 10 µM. DPPE is cytotoxic to S10 and MCF-7 cells (IC50s = 7.5 and 12 µM) and inhibits antigen-induced histamine release in isolated rat mast cells (IC50 = 65-85 µM).{57919,57918} It decreases uterine size in immature oophorectomized rats in a dose-dependent manner.{57917} DPPE (4 mg/kg) protects bone marrow progenitor cells from cytotoxicity induced by doxorubicin (Item No. 15007) in mice.{57919}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine
  • Correlated keywords
    • 98774-23-3 BMS21738001 BMS217380 21738001 MCF7
  • Product Overview:
    DPPE is a ligand for the antiestrogen-binding site (AEBS; Ki = 55.6 nM in rat liver microsomes) and derivative of tamoxifen (Item No. 11629).{57916} It is selective for the AEBS over the estrogen receptor when used at a concentration of 10 µM. DPPE is cytotoxic to S10 and MCF-7 cells (IC50s = 7.5 and 12 µM) and inhibits antigen-induced histamine release in isolated rat mast cells (IC50 = 65-85 µM).{57919,57918} It decreases uterine size in immature oophorectomized rats in a dose-dependent manner.{57917} DPPE (4 mg/kg) protects bone marrow progenitor cells from cytotoxicity induced by doxorubicin (Item No. 15007) in mice.{57919}

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