DK-AH 269

DK-AH 269

CAT N°: 21425
Price:

From 60.00 51.00

DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).{30118} DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.{33670} Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.{30118} DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.{30118}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride
  • Correlated keywords
    • 147541-45-5 DKAH269 DK-AH-269 bradycardia
  • Product Overview:
    DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).{30118} DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.{33670} Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.{30118} DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.{30118}

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