Dityrosine (hydro<wbr/>chloride)

Dityrosine (hydrochloride)

CAT N°: 27657
Price:

From 145.00 123.25

Dityrosine is a protein oxidation product that is formed by intermolecular cross-linking of two tyrosyl radicals generated from the interaction between reactive oxygen species (ROS) and tyrosine.{47802,47803} Intragastric administration of dityrosine (320 µg/kg per day) decreases hippocampal expression of the NMDA receptor subunits Nr1, Nr2a, and Nr2b and induces memory impairments in a novel object recognition test in mice.{47803} It increases fasting blood glucose levels and decreases plasma insulin levels and pancreatic expression of the insulin synthesis-related genes Ins2, Pdx1, and MafA in mice.{47804} Increased levels of dityrosine are positively correlated with various diseases, including autism spectrum disorder, cataracts, Alzheimer’s disease, Parkinson’s disease, atherosclerosis, and cystic fibrosis.{47805,47806}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • ?3,?3′-diamino-6,6′-dihydroxy-[1,1′-biphenyl]-3,3′-dipropanoic acid, dihydrochloride
  • Correlated keywords
    • 980-21-2 inter-molecular Nr 1 2a 2b Ins 2 Pdx Maf A
  • Product Overview:
    Dityrosine is a protein oxidation product that is formed by intermolecular cross-linking of two tyrosyl radicals generated from the interaction between reactive oxygen species (ROS) and tyrosine.{47802,47803} Intragastric administration of dityrosine (320 µg/kg per day) decreases hippocampal expression of the NMDA receptor subunits Nr1, Nr2a, and Nr2b and induces memory impairments in a novel object recognition test in mice.{47803} It increases fasting blood glucose levels and decreases plasma insulin levels and pancreatic expression of the insulin synthesis-related genes Ins2, Pdx1, and MafA in mice.{47804} Increased levels of dityrosine are positively correlated with various diseases, including autism spectrum disorder, cataracts, Alzheimer’s disease, Parkinson’s disease, atherosclerosis, and cystic fibrosis.{47805,47806}

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