Liver-expressed antimicrobial peptide 2 (LEAP-2) plays a crucial role in the innate immune system.

Liver-expressed antimicrobial peptide 2 () plays a crucial role in the innate immune system, acting as a natural defense against various threats such as bacteria, fungi and viruses. In addition, it acts as an antagonist of ghrelin, an appetite-stimulating hormone, the reduction of which signals satiety.

LEAP-2 also helps regulate inflammatory responses and maintain the balance of the intestinal microbiota, thus promoting overall gastrointestinal health. Understanding the function and regulation of LEAP-2 is essential for developing new therapeutic strategies against infectious diseases, inflammatory conditions, gastrointestinal disorders and obesity-related metabolic disorders. LEAP-2 could also serve as a biomarker for some of these diseases. Thus, research on LEAP-2 is essential to deepen our understanding of its role in various metabolic mechanisms.