24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Didanosine is an antiviral nucleoside analog and an inhibitor of reverse transcriptase.{38655} It undergoes cellular amination and phosphorylation to its active triphosphate form, 2′,3′-dideoxyadenosine 5′-triphosphate (ddATP; Item No. 17460). Didanosine inhibits human T cell leukemia virus type 1 (HTLV-1) reverse transcriptase activity (IC50 = 30 nM).{60704} It inhibits the replication of HIV-1 clinical isolates containing various mutations in the gene encoding reverse transcriptase, pol, in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-11.1 ?M).{38656} Didanosine inhibits proliferation and differentiation of primary human skeletal muscle cells (IC50s = 1 and 0.1 mM, respectively), as well as decreases the activities of mitochondrial complex IV, also known as cytochrome c oxidase, and mitochondrial complex II, also known as succinate dehydrogenase, in the same cells when used at a concentration of 1 mM.{38657} In vivo, didanosine protects mice from HIV infection (EC50 = 13.7 mg/kg).{38658} Formulations containing didanosine have been used in the treatment of HIV-1 infections.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 mg, 250 mg, 500 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 69655-05-6 |
| Molecular formula | C10H12N4O3 |
| Smiles | OC[C@@H]1CC[C@H](N2C=NC3=C2N=CNC3=O)O1 |
| Molecular weight | 236,2 |
| Custom code | 2932.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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