Dicoumarol

Dicoumarol

CAT N°: 20764
Price:

From 29.00 24.65

Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 ?M BSA, respectively.{38128} It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 ?M, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 ?M) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-? and LPS-induced NF-?B activation in HeLa cells.{38129} It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 ?M) by suppressing JNK activation.{38130}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,3′-methylenebis[4-hydroxy-2H-1-benzopyran-2-one
  • Correlated keywords
    • acadyl acavyl antitrombosin baracoumin cuma cumid dicoumal dicoumarin dicuman dicumarine dicumarol dicumol dufalone kumoran melitoxin NC-034 NC034 NSC17860 NSC221570 NSC41834 temparin trombosan HEK-293 TRAF-2 MCF7 TNFa TNF-a TNF? bishydroxycoumarin NQO-1 anti-proliferative PaCa2 MIAPaCa2 HCT-116 MEKK-1 lipopolysaccharide NFkB c?Jun N?terminal hNQO1
  • Product Overview:
    Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 ?M BSA, respectively.{38128} It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 ?M, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 ?M) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-? and LPS-induced NF-?B activation in HeLa cells.{38129} It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 ?M) by suppressing JNK activation.{38130}

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