Dextrometh<wbr/>orphan-d<sub>3</sub> (CRM)

Dextromethorphan-d3 (CRM)

CAT N°: ISO60204
Price:

203.00 172.55

Dextromethorphan-d3 (CRM) contains three deuterium atoms at the 17-methyl group. It is intended for use as an internal standard for the quantification of dextromethorphan by GC- or LC-mass spectrometry. Dextromethorphan (DXM) (Item Nos. ISO60141 | 13950) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, DXM is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 ?M) and nicotinic receptors (IC50s = 0.7-3.9 ?M) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 ?M) and voltage-gated sodium channels (IC50 = 78 ?M).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Reference Materials RMs and Certified Reference Materials CRMs are dispatched directly to the end-user in accordance with ISO requirements. Please check regulation status before ordering; additionel fees can apply.

  • Synonyms
    • 3-methoxy-17-(methyl-d3)-, (9a,13a,14a)-morphinan
  • Correlated keywords
    • ISO forensic science analytical reference standard biochemical mass spectrometry GC-MS GC/MS LC-MS LC/MS quantify quantification gas chromatography liquid internal isotopes opioid pain
  • Product Overview:
    Dextromethorphan-d3 (CRM) contains three deuterium atoms at the 17-methyl group. It is intended for use as an internal standard for the quantification of dextromethorphan by GC- or LC-mass spectrometry. Dextromethorphan (DXM) (Item Nos. ISO60141 | 13950) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, DXM is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 ?M) and nicotinic receptors (IC50s = 0.7-3.9 ?M) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 ?M) and voltage-gated sodium channels (IC50 = 78 ?M).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}

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