€615.00 €522.75
Desmin is a type III muscle-specific intermediate filament protein.{53009} It is composed of a central rod containing four ?-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. It is expressed specifically in muscle cells beginning in early development and in skeletal and cardiac muscle progenitor cells in the adult. Desmin associates with the cardiac and skeletal muscle sarcolemma at costameres and is involved in sarcolemma organization. In cardiac muscle, it is found at the desmosomes of intercalated disks. It also associates with mitochondria, and desmin-deficient mice have mitochondrial abnormalities, which lead to heart failure. Desmin self-polymerizes but can also form heteropolymers with other type III or -IV intermediate filament proteins.{42183} Mutations in DES, the gene encoding desmin, disrupt desmin self-assembly, lead to accumulation of cytoskeletal protein aggregates, and are associated with desmin-related myopathies that affect both skeletal and cardiac muscle.{58062,58063} Cayman’s Desmin Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes desmin at approximately 54 kDa from human and mouse samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to human desmin |
| Clone | RM234 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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