Desipramine-d₄ (hydrochloride)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-2,4,6,8-d4-5-propanamine, monohydrochloride
• Correlated keywords
  • 116744-71-9 deuterated deuterium GCMS LCMS monodemethyl mono Demethyl Desmethyl imipramine Norimipramine Nortimil Pertofran Pertofrane Petylyl Norpramin EX 4355 EX4355 JB 8181 JB8181 NSC114901 Petilil RMI 9384A RMI9384A Desipramin Methylaminopropyliminodibenzyl anti depressant 5ht 2A ? 2 H 1 2 A Kir 3 GIRK 1 2 4 G 35030 G35020
• Product Overview:
  Desipramine-d4 is intended for use as an internal standard for the quantification of desipramine by GC- or LC-MS. Desipramine is a tricyclic antidepressant and an active metabolite of imipramine (Item No. 15890).{32156} It inhibits the serotonin (5-HT) and norepinephrine transporters (Kis = 163 and 3.5 nM for human SERT and NET, respectively) and is an antagonist of the 5-HT receptor subtype 5-HT2A and the ?1-adrenergic receptor (?1-AR), as well as histamine H1 and muscarinic acetylcholine receptors (mAChRs; Kis = 115, 23, 31, and 37 nM, respectively). Desipramine is selective for the 5-HT2A receptor over the 5-HT1A receptor (Ki = 2,272 nM) and for ?1-AR over ?2-AR (Ki = 1,379 nM). It also selectively inhibits G protein-activated inward rectifier potassium channel (GIRK), also known as Kir3, currents in Xenopus oocytes expressing human GIRK1 and GIRK2 or human GIRK1 and GIRK4 (IC50s = 36.4 and 53.9 µM, respectively) over Kir1.1 or Kir2.1 currents in Xenopus oocytes expressing the human channels (IC50s = >100 µM for both).{67027} Desipramine (3.2 mg/kg) decreases immobility time in the forced swim test in mice.{67028} It also decreases flinching, as well as paw biting and licking, in the second phase of the formalin test in rats.{67029} Formulations containing desipramine have been used in the treatment of depression.