Desethoxy Quetiapine (hydro<wbr/>chloride)

Desethoxy Quetiapine (hydrochloride)

CAT N°: 35410
Price:

From 253.00 215.05

Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Item No. 14152).{57986} It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM).{57987,57986} Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.{57986}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol, dihydrochloride
  • Correlated keywords
    • 329216-67-3 anti-psychotic P-450 CYP-3A5 CYP3A-5 desethoxyquetiapine desalkyl
  • Product Overview:
    Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Item No. 14152).{57986} It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM).{57987,57986} Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.{57986}

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