24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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€496.00 €421.60
Defensin HNP-1 is a peptide secreted by polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.{41472} It induces lysis of mammalian cells when used at concentrations of 25 and 100 ?g/ml, respectively.{41473} It also completely inhibits secretion of the exotoxin superantigen TSS toxin-1 (TSST-1) from S. aureus when used at a concentration of 50 ng/ml and inhibits anthrax lethal toxin (IC50 = 148 nM).{41474,36484} HNP-1 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 23.2 and 12.9 nM, respectively).{41476} It induces lysis and leakage from liposomes composed of dipalmitoyl phosphatidylcholine (DPPC; Item No. 10009473) and dioleyl phosphatidylserine (DOPS).{36485} In vivo, HNP-1 (5 ?g) increases interferon ? (IFN-?) production by human plasmacytoid dendritic cells (pDCs) injected into nude mice.{36486}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C150H222N44O38S6 • XCF3COOH |
| Smiles | [H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C2=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)C)=O)=O)CSSC[C@H](N4)C5=O)=O)C)=O)=O)=O)=O)CSSC[C@H](N2)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C4=O)CC6=CC=CC=C6)=O)C)=O)CC7=CNC8=C7C=CC=C8)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O)=O)=O)CC=CC=C(O)C=C)=O)CSSC[C@H](N5)C(O)=O)=O)C.OC(C(F)(F)F)=O |
| Molecular weight | 3442 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| Custom code | 3504.00 |
| UNSPSC code | 12352100 |
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