Decynium-22

Decynium-22

CAT N°: 29494
Price:

From 74.00 62.90

Decynium-22 is an inhibitor of monoamine transporters and organic cation transporters (OCTs).{48740} It inhibits the plasma membrane monoamine, serotonin (5-HT), norepinephrine, and dopamine monoamine transporters (IC50s = 1.1, 7.9, 30, and 12.9 µM, respectively), and OCT2 and OCT3 (IC50s = 10 and 0.2 µM, respectively) in radioligand binding assays. Decynium-22 also inhibits binding of the ?1-adrenergic receptor antagonist prazosin (Item No. 15023) in mouse hippocampal homogenates (IC50 = 60 nM).{48741} It decreases the time stress-sensitive Wistar Kyoto, but not stress-resistant Long-Evans, rats spend immobile in the forced swim test, indicating antidepressant-like activity, when administered at doses of 1 and 10 µg/kg.{48742}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]-quinolinium, monoiodide
  • Correlated keywords
    • 188653-03-4 20766-49-8 Decynium22 5HT OCT 2 3 Iodide N,N ?-Diethylpseudoisocyanin pseudoIsocyanine pseudo Isocyanine Diethylcyanine Diethyl cyanine D22 anti depressant
  • Product Overview:
    Decynium-22 is an inhibitor of monoamine transporters and organic cation transporters (OCTs).{48740} It inhibits the plasma membrane monoamine, serotonin (5-HT), norepinephrine, and dopamine monoamine transporters (IC50s = 1.1, 7.9, 30, and 12.9 µM, respectively), and OCT2 and OCT3 (IC50s = 10 and 0.2 µM, respectively) in radioligand binding assays. Decynium-22 also inhibits binding of the ?1-adrenergic receptor antagonist prazosin (Item No. 15023) in mouse hippocampal homogenates (IC50 = 60 nM).{48741} It decreases the time stress-sensitive Wistar Kyoto, but not stress-resistant Long-Evans, rats spend immobile in the forced swim test, indicating antidepressant-like activity, when administered at doses of 1 and 10 µg/kg.{48742}

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