24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. gigas and has diverse biological activities.{42374,42375,42376,42377,42378} It inhibits the growth of K562, HL-60, KG-1, SK-BR-3, AGS, A549, HeLa, HepG2, and G-361 cancer cells (ED50s = 24-56 ?M) and decreases estrogen-stimulated growth of MCF-7 breast cancer cells in a concentration-dependent manner via decreased estrogen receptor ? (ER?) protein levels and signaling activity.{42374,42375} Decursinol angelate (30 ?M) activates PKC purified from rat brain.{42374} It selectively inhibits the cytochrome P450 (CYP) isoform CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (Kis = 67.56, 872.5, and 853.9 ?M, respectively).{42376} Decursinol angelate (0.01-10 ?M) reduces cytotoxicity and malondialdehyde (MDA) production induced by amyloid-? (23-35) (A?25-35) and increases superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in PC12 cells.{42377} In mice, decursinol angelate (200 mg/kg) has antinociceptive activity in the tail flick and hot plate tests and reduces acetic acid-induced writhing as well as decreases production of the pro-inflammatory cytokines TNF-? and IL-1?.{42378}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 130848-06-5 |
| Molecular formula | C19H20O5 |
| Smiles | O=C1C=CC(C=C(C[C@H](OC(/C(C)=CC)=O)C(C)(C)O2)C2=C3)=C3O1, O=C1C=CC(C=C(C[C@H](OC(/C(C)=CC)=O)C(C)(C)O2)C2=C3)=C3O1, O=C1C=CC(C=C(C[C@H](OC(/C(C)=CC)=O)C(C)(C)O2)C2=C3)=C3O1, O=C1C=CC(C=C(C[C@H](OC(/C(C)=CC)=O)C(C)(C)O2)C2=C3)=C3O1 |
| Molecular weight | 328,4 |
| Custom code | 2932.20 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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