Amyloid-? (1-8, A2V) Peptide
Amyloid-? (1-8, A2V) Peptide
Amyloid-? (1-8, A2V) is a truncated form of amyloid-? (A?) that contains a valine to alanine substitution at position 2...
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€177.00 €150.45
€177.00 €150.45
Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2.{24026} Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 µM, respectively), blocking G2 arrest.{24024,24029} Because it does not significantly affect the activity of ataxia-telangiectasia mutated (ATM) or ATM-Tad2-related protein, DBH is a useful tool for studying the roles of Chk1 and Chk2 in DNA repair and cell cycle regulation.{24024} DBH also inhibits MAP kinase kinase 1 (IC50 = 881 nM), glycogen synthase kinase 3? (IC50 = 1.39 ?M), cyclin-dependent kinase 5/p25 (IC50 = 9.12 ?M), protein tyrosine kinase 6 (IC50 = 0.6 ?M), and other kinases largely unrelated to DNA damage/repair and cell cycling.{24027,24028,24025,24023}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 75593-17-8 |
| Molecular formula | C11H11N5O2 |
| Smiles | O=C1/C(NC(N)=N1)=C2C(C=CN3)=C3C(NCC/2)=O |
| Molecular weight | 245,2 |
| Formulation | A yellow solid |
| Purity | ≥95% |
| Custom code | 2922.19 |
| UNSPSC code | 12352100 |
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