Dapa<wbr/>gliflozin-d<sub>5</sub>

Dapagliflozin-d5

CAT N°: 22611
Price:

From 303.00 257.55

Dapagliflozin-d5 is intended for use as an internal standard for the quantification of dapagliflozin (Item No. 11574) by GC- or LC-MS. Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2; IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively).{22762} It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM. Dapagliflozin (0.1 and 1 mg/kg) increases urinary glucose levels in normal and Zucker diabetic rats. It decreases fasting and fed plasma glucose levels in Zucker diabetic rats when administered at doses of 0.01, 0.1, and 1 mg/kg.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-(ethoxy-1,1,2,2,2-d5)phenyl]methyl]phenyl]-D-glucitol
  • Correlated keywords
    • deuterated deuterium gases chromatography isotope GC/MS LC-MS LC/MS GCMS LCMS SGLT-1 2 BMS 512148 BMS512148 farxiga forxiga cotransporter
  • Product Overview:
    Dapagliflozin-d5 is intended for use as an internal standard for the quantification of dapagliflozin (Item No. 11574) by GC- or LC-MS. Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2; IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively).{22762} It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM. Dapagliflozin (0.1 and 1 mg/kg) increases urinary glucose levels in normal and Zucker diabetic rats. It decreases fasting and fed plasma glucose levels in Zucker diabetic rats when administered at doses of 0.01, 0.1, and 1 mg/kg.

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